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Article

A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration.

Endothelium : journal of endothelial cell research - 1 Jan 2000

Huang Fei, Mehta Dolly, Predescu Sanda, Kim Kwang S, Lum Hazel

Abstract excerpt

Abundant evidence documents the highly proinflammatory actions of lysophosphatidylcholine (LPC). Further, LPC, found in high amounts in oxidized low-density lipoprotein (LDL), is implicated as an atherogenic factor. In endothelial cells, LPC impairs endothelial barrier function through GPR4, a no...

Read the complete abstract on PubMed

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Share to Endothelial Cells
Share to Endothelium, Vascular
Share to Fluorescent Antibody Technique, Indirect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luminescent Measurements

Share to Monocytes

Share to Receptors, G-Protein-Coupled

Share to Retroviridae

Share to RNA, Small Interfering

Source

Identifiers

PMID: 17364894
DOI: 10.1080/10623320601177288

Genes

GPR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17364894-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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