Article

Brain endothelial cell tissue-nonspecific alkaline phosphatase (TNAP) activity promotes maintenance of barrier integrity <i>via</i> the ROCK pathway

2021-03-26

Abstract excerpt

Blood-brain barrier (BBB) dysfunction is a key feature in many neuroinflammatory diseases. Yet, no therapies exist to effectively mitigate BBB dysfunction. A strategy to bridge this knowledge gap requires an examination of proteins localized to brain microvascular endothelial cells (BMECs) and evaluating their role in preserving barrier integrity. Tissue-nonspecific alkaline phosphatase (TNAP) is highly abundant i...

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Literature Corpus work: 2e0c5743-d9b3-5370-b757-1cf6dad9693c
DOI: 10.1101/2021.03.25.437097

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