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Article

Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors.

The Biochemical journal - 1 Jul 2005

Inagaki Yuichi, Pham Trucchi T, Fujiwara Yuko, Kohno Takayuki, Osborne Daniel A, Igarashi Yasuyuki, Tigyi Gabor, Parrill Abby L

Abstract excerpt

Synergistic computational and experimental studies provided previously unforeseen details concerning the structural basis of S1P (sphingosine 1-phosphate) recognition by the S1P4 G-protein-coupled receptor. Similarly to reports on the S1P1 receptor, cationic and anionic residues in the third transmembrane domain (R3.28 and E3.29 at positions 124 and 125) form ion pairs with the phosphate and ammonium of S1P, and...

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Identifiers

PMID: 15733055
DOI: 10.1042/BJ20050046
PMCID: PMC1184551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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