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Article

Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease.

Experimental neurology - 1 Aug 2012

Duncan Marilyn J, Smith J Tyler, Franklin Kathleen M, Beckett Tina L, Murphy M Paul, St Clair Daret K, Donohue Kevin D, Striz Martin, O'Hara Bruce F

Abstract excerpt

Profound disruptions of circadian rhythms and sleep/wake cycles constitute a major cause of institutionalization of AD patients. This study investigated whether a rodent model of AD, APP(NLH/NLH)/PS-1(P264L/264L) (APPxPS1) mice, exhibits circadian alterations. The APPxPS1 mice were generated using CD-1/129 mice and Cre-lox knock-in technology to "humanize" the mouse amyloid (A)β sequence and create a presenilin-1...

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Identifiers

PMID: 22634208
DOI: 10.1016/j.expneurol.2012.05.011

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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