Article
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits.
Nature genetics - 1 Nov 2019
Zhao Bingxin, Luo Tianyou, Li Tengfei, Li Yun, Zhang Jingwen, Shan Yue, Wang Xifeng, Yang Liuqing, Zhou Fan, Zhu Ziliang, Zhu Hongtu
Abstract excerpt
Volumetric variations of the human brain are heritable and are associated with many brain-related complex traits. Here we performed genome-wide association studies (GWAS) of 101 brain volumetric phenotypes using the UK Biobank sample including 19,629 participants. GWAS identified 365 independent genetic variants exceeding a significance threshold of 4.9 × 10-10, adjusted for testing multiple phenotypes. A...
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