Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes.

Abstract excerpt

Heritability analysis plays a central role in quantitative genetics to describe genetic contribution to human complex traits and prioritize downstream analyses under large-scale phenotypes. Existing works largely focus on modeling single phenotype and currently available multivariate phenotypic methods often suffer from scaling and interpretation. In this article, motivated by understanding how genetic...

Topics

• Alzheimer Disease
• Bayes Theorem
• Humans
• Neuroimaging
• Phenotype
• Polymorphism, Single Nucleotide