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Article

Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits.

Nature communications - 17 May 2021

Zhao Bingxin, Shan Yue, Yang Yue, Yu Zhaolong, Li Tengfei, Wang Xifeng, Luo Tianyou, Zhu Ziliang, Sullivan Patrick, Zhao Hongyu, Li Yun, Zhu Hongtu

Abstract excerpt

Structural variations of the human brain are heritable and highly polygenic traits, with hundreds of associated genes identified in recent genome-wide association studies (GWAS). Transcriptome-wide association studies (TWAS) can both prioritize these GWAS findings and also identify additional gene-trait associations. Here we perform cross-tissue TWAS analysis of 211 structural neuroimaging and discover 278...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34001886
DOI: 10.1038/s41467-021-23130-y
PMCID: PMC8128893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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