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A genetically informed brain atlas for enhancing brain imaging genomics.

Nature communications - 14 Apr 2025

Bao Jingxuan, Wen Junhao, Chang Changgee, Mu Shizhuo, Chen Jiong, Shivakumar Manu, Cui Yuhan, Erus Guray, Yang Zhijian, Yang Shu, Wen Zixuan, Zhao Yize, Kim Dokyoon, Duong-Tran Duy, Saykin Andrew J, Zhao Bingxin, Davatzikos Christos, Long Qi, Shen Li

Abstract excerpt

Brain imaging genomics has manifested considerable potential in illuminating the genetic determinants of human brain structure and function. This has propelled us to develop the GIANT (Genetically Informed brAiN aTlas) that accounts for genetic and neuroanatomical variations simultaneously. Integrating voxel-wise heritability and spatial proximity, GIANT clusters brain voxels into genetically informed regions,...

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Brain
Brain Mapping
Genomics
Magnetic Resonance Imaging
Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 40229250
DOI: 10.1038/s41467-025-57636-6
PMCID: PMC11997130

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