Article
A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A.
Molecular and cellular biology - 1 Aug 2001
Zhang J S, Moncrieffe M C, Kaczynski J, Ellenrieder V, Prendergast F G, Urrutia R
Abstract excerpt
Sp1-like proteins are defined by three highly homologous C(2)H(2) zinc finger motifs that bind GC-rich sequences found in the promoters of a large number of genes essential for mammalian cell homeostasis. Here we report that TIEG2, a transforming growth factor beta-inducible Sp1-like protein with antiproliferative functions, represses transcription through recruitment of the mSin3A-histone deacetylase complex....
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