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Article

SIN3B promotes integrin αV subunit gene transcription and cell migration of hepatocellular carcinoma

12 Sept 2018

Abstract excerpt

Paired amphipathic helix protein (SIN3B) is a transcription corepressor for many genes. Here we show a different regulation mechanism of integrin αV gene expression by SIN3B in human hepatocellular carcinoma (HCC). We first observed a close relationship between Integrin αV and SIN3B expressions in HCC patients and tumor cell lines with different metastatic potentials. Overexpression of SIN3B significantly...

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PMID: 30215728
DOI: 10.1093/jmcb/mjy050

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