PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.

doi:10.1126/science.abk0410

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Article

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.

Science (New York, N.Y.) - 10 Dec 2021

Gulluni Federico, Prever Lorenzo, Li Huayi, Krafcikova Petra, Corrado Ilaria, Lo Wen-Ting, Margaria Jean Piero, Chen Anlu, De Santis Maria Chiara, Cnudde Sophie J, Fogerty Joseph, Yuan Alex, Massarotti Alberto, Sarijalo Nasrin Torabi, Vadas Oscar, Williams Roger L, Thelen Marcus, Powell David R, Schueler Markus, Wiesener Michael S, Balla Tamas, Baris Hagit N, Tiosano Dov, McDermott Brian M, Perkins Brian D, Ghigo Alessandra, Martini Miriam, Haucke Volker, Boura Evzen, Merlo Giorgio Roberto, Buchner David A, Hirsch Emilio

Abstract excerpt

Cytokinetic membrane abscission is a spatially and temporally regulated process that requires ESCRT (endosomal sorting complexes required for transport)–dependent control of membrane remodeling at the midbody, a subcellular organelle that defines the cleavage site. Alteration of ESCRT function can lead to cataract, but the underlying mechanism and its relation to cytokinesis are unclear. We found a lens-specific...

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Identifiers

PMID: 34882480
DOI: 10.1126/science.abk0410
PMCID: PMC7612254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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