Article

Beyond the surface: plasmalogens are dispensable for retinal integrity and fertility in the mouse

2026-04-12

Abstract excerpt

Ether lipids and their subclass, the plasmalogens, are critical regulators of membrane organization, signaling, and stress responses in multiple tissues. Inborn errors in their anabolism cause severe multi-organ diseases such as Rhizomelic Chondrodysplasia Punctata and related peroxisomal disorders. The Gnpat knockout mouse model, characterized by total ether lipid deficiency, recapitulates key features of this d...

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Literature Corpus work: ae05e478-a11a-59e5-bd97-12a0b8ca6342
DOI: 10.64898/2026.04.09.717382

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