Oncogenic GNAQ/11-induced remodeling of the IP3/Calcium signaling pathway protects Uveal Melanoma against Calcium-driven cell death

Abstract excerpt

<h4>ABSTRACT</h4> Despite being considered a rare tumor, uveal melanoma (UVM) is the most common adult intraocular malignancy. With a poor prognosis and limited treatment options, up to 50% of patients develop metastases, primarily in the liver. A range of mutations and chromosomal aberrations with significant prognostic value has been associated with UVM pathogenesis. The most frequently mutated genes are GNAQ a...

Topics

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• Focal Adhesion Kinase 1
• GTP-Binding Protein alpha Subunits
• GTP-Binding Protein alpha Subunits, Gq-G11
• Ocular Oncology and Treatments
• Oncogenes
• Phospholipase C beta
• Uveal Melanoma
• Uveal Neoplasms

Identifiers and source

Literature Corpus work

b8764d5b-66ec-5a7a-8008-35569d71db0d

DOI

10.1101/2024.11.25.625282