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Article

Genotype, Age, Genetic Background, and Sex Influence Epha2-Related Cataract Development in Mice.

Investigative ophthalmology & visual science - 2 Sept 2021

Dave Alpana, Craig Jamie E, Alamein Mohammad, Skrzypiec Karina, Beltz Justin, Pfaff Annalise, Burdon Kathryn P, Ercal Nuran, de Iongh Robb U, Sharma Shiwani

Abstract excerpt

Purpose: Age-related cataract is the leading cause of blindness worldwide. Variants in the EPHA2 gene increase the disease risk, and its knockout in mice causes cataract. We investigated whether age, sex, and genetic background, risk factors for age-related cataract, and Epha2 genotype influence Epha2-related cataract development in mice. Methods: Cataract development was monitored in Epha2+/+, Epha2+/-, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lens, Crystalline

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Identifiers

PMID: 34495288
DOI: 10.1167/iovs.62.12.3
PMCID: PMC8431977

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