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Article

Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.

Leukemia - 1 Apr 2022

Wilson Elisabeth R, Helton Nichole M, Heath Sharon E, Fulton Robert S, Payton Jacqueline E, Welch John S, Walter Matthew J, Westervelt Peter, DiPersio John F, Link Daniel C, Miller Christopher A, Ley Timothy J, Spencer David H

Abstract excerpt

Recurrent mutations in IDH1 or IDH2 in acute myeloid leukemia (AML) are associated with increased DNA methylation, but the genome-wide patterns of this hypermethylation phenotype have not been comprehensively studied in AML samples. We analyzed whole-genome bisulfite sequencing data from 15 primary AML samples with IDH1 or IDH2 mutations, which identified ~4000 focal regions that were uniquely hypermethylated in...

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Topics

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Share to DNA Methylation
Share to CD34 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNMT3A gene

Share to ETV6 gene

Share to Isocitrate Dehydrogenase

Share to Leukemia, Myeloid, Acute

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Share to Regulatory Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 34873300
DOI: 10.1038/s41375-021-01476-y
PMCID: PMC8979817

Genes

CD34
IDH1
IDH2
DNMT3A
ETV6
MYC
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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