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Article

DNA methylation and hydroxymethylation patterns in acute myeloid leukemia patients with mutations in DNMT3A and IDH1/2 and their combinations.

Cancer biomarkers : section A of Disease markers - 1 Jan 2019

Šestáková Šárka, Krejčík Zdeněk, Folta Adam, Cerovská Ela, Šálek Cyril, Merkerová Michaela Dostálová, Pecherková Pavla, Ráčil Zdeněk, Mayer Jiří, Cetkovský Petr, Remešová Hana

Abstract excerpt

BACKGROUND: Aberrant epigenetic patterns are a hallmark of acute myeloid leukemia (AML). Mutations in profound epigenetic regulators DNMT3A and IDH1/2 often occur concurrently in AML. OBJECTIVES: The aim was to analyze DNA methylation, hydroxymethylation and mRNA expression profiles in AML with mutations in DNMT3A and IDH1/2 (individually and in combinations). METHODS: Infinium MethylationEPIC BeadChip (Illumina)...

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Topics

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Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to Gene Expression Profiling

Share to Granzymes

Share to Isocitrate Dehydrogenase

Share to Leukemia, Myeloid, Acute

Share to Leukocytes, Mononuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 30988238
DOI: 10.3233/CBM-182176
PMCID: PMC13082415

Genes

IDH1
DNMT3A
GZMB
CD34

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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