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Article

iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice.

PLoS pathogens - 1 Jun 2009

De Trez Carl, Magez Stefan, Akira Shizuo, Ryffel Bernhard, Carlier Yves, Muraille Eric

Abstract excerpt

Leishmania major parasites reside and multiply in late endosomal compartments of host phagocytic cells. Immune control of Leishmania growth absolutely requires expression of inducible Nitric Oxide Synthase (iNOS/NOS2) and subsequent production of NO. Here, we show that CD11b+ CD11c+ Ly-6C+ MHC-II...

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Topics

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Share to Dendritic Cells
Share to Leishmania major
Share to Leishmaniasis, Cutaneous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luminescent Proteins

Share to Lymph Nodes

Share to Nitric Oxide Synthase Type II

Share to Receptors, CCR2

Share to Statistics, Nonparametric

Source

Open in PubMed Open full text

Identifiers

PMID: 19557162
DOI: 10.1371/journal.ppat.1000494
PMCID: PMC2695779

Genes

CCR2
NOS2
TLR9
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19557162-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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