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Article

Influence of HNF4α and HNF4α-AS1 gene variants on the risk of anti-tuberculosis drugs-induced hepatotoxicity.

Annals of palliative medicine - 1 Nov 2021

Zhang Jingwei, Liu Xingren, He Hai, Zhou Wei, Liu Yao, Jiang Peidu, Feng Jing, Zhou Yi, Meng Xianglong, Deng Fei

Abstract excerpt

BACKGROUND: The most serious and common complication of the medication recommended by World Health Organization (WHO) for tuberculosis (TB) is anti-tuberculosis drugs-induced hepatotoxicity (ATDH). Pregnane X receptor (PXR) is a key factor of ATDH, while Hepatocyte nuclear factor 4α (HNF4α) and hepatocyte nuclear factor 4 alpha-antisense-1 (HNF4α-AS1) may have co-regulating relationship with PXR. This study aimed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34872298
DOI: 10.21037/apm-21-2924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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