Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity.

doi:10.1080/00498254.2022.2092783

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Article

Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity.

Xenobiotica; the fate of foreign compounds in biological systems - 1 May 2022

Wang Ning, Guo Shaochen, Liu Haiting, Ding Yangming, Yao Rong, Liu Zhongquan, Zhu Hui, Chen Xi, Yang Xinting, Chen Xiaoyou, Lu Yu

Abstract excerpt

The recommended treatment regimen for tuberculosis is a combination of agents with antitubercular activity, during which hepatotoxicity is one of the most common side effects. In addition to the N-acetyltransferase 2 (NAT2) genotype, rs3814055 in nuclear receptor subfamily 1, group I, member 2 (NR1I2) has been demonstrated to be associated with anti-tuberculosis drug-induced hepatotoxicity (ATDH), but previous...

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PMID: 35723590
DOI: 10.1080/00498254.2022.2092783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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