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Article

Heme oxygenase-1 and hemopexin gene polymorphisms and the risk of anti-tuberculosis drug-induced hepatotoxicity in China.

Pharmacogenomics - 1 May 2022

Liu Wenpei, Lu Lihuan, Pan Hongqiu, He Xiaomin, Zhang Meiling, Wang Nannan, Zhu Jia, Yi Honggang, Tang Shaowen

Abstract excerpt

Objective: To assess whether the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH) might be influenced by heme oxygenase-1 (HMOX1) and hemopexin (HPX) gene polymorphisms. Methods: A dynamic anti-tuberculosis treatment cohort was constructed, and the 1:4 matched nested case-control study was analysed. Eight single-nucleotide polymorphisms (SNPs) of the two genes were selected for genotyping and...

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Identifiers

PMID: 35470713
DOI: 10.2217/pgs-2022-0015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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