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Article

Genome-Wide Association and Replication Study of Hepatotoxicity Induced by Antiretrovirals Alone or with Concomitant Anti-Tuberculosis Drugs.

Omics : a journal of integrative biology - 1 Apr 2017

Petros Zelalem, Lee Ming Ta Michael, Takahashi Atsushi, Zhang Yanfei, Yimer Getnet, Habtewold Abiy, Schuppe-Koistinen Ina, Mushiroda Taisei, Makonnen Eyasu, Kubo Michiaki, Aklillu Eleni

Abstract excerpt

Drug-induced hepatotoxicity (DIH) is a common adverse event that is associated with both antiretroviral (ARV) and anti-tuberculosis drugs (ATD). Moreover, the genetic variations predisposing ARV- and ARV-ATD-induced liver toxicity in African populations are not well investigated, despite the two diseases being the major global health problems in sub-Saharan Africa. We performed a genome-wide association study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28388302
DOI: 10.1089/omi.2017.0019
PMCID: PMC5395044

Genes

ERN1

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