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Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity

18 Feb 2019

Abstract excerpt

A combination therapy of multiple drugs including isoniazid, rifampicin, ethambutol and pyrazinamide has been proven to be an effective option for the vast majority of tuberculosis (TB) patients. However, various adverse drug reactions (ADRs) limit its merit, with anti-TB drug-induced hepatotoxicity (ATDH) being a common and sometimes severe ADR. This study aimed to investigate the association between...

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PMID: 30778091
DOI: 10.1038/s41598-018-38452-z

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