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Article

Genetic Polymorphisms of Glutathione S-Transferase P1 (GSTP1) and the Incidence of Anti-Tuberculosis Drug-Induced Hepatotoxicity.

PloS one - 1 Jan 2016

Wu Shouquan, Wang You-Juan, Tang Xiaoyan, Wang Yu, Wu Jingcan, Ji Guiyi, Zhang Miaomiao, Chen Guo, Liu Qianqian, Sandford Andrew J, He Jian-Qing

Abstract excerpt

BACKGROUND: Anti-tuberculosis drug-induced hepatotoxicity (ATDH) is one of the most common adverse effects associated with tuberculosis (TB) therapy. Animal studies have demonstrated important roles of glutathione S-transferases in the prevention of chemical-induced hepatotoxicity. The aim of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) of glutathione S-transferase...

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Share to Antitubercular Agents
Share to Chemical and Drug Induced Liver Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GSTP1 gene

Share to Genetic Predisposition to Disease

Share to Glutathione S-Transferase pi

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Share to Polymorphism, Single Nucleotide

Share to Tuberculosis, Pulmonary

Source

Open in PubMed Open full text

Identifiers

PMID: 27281183
DOI: 10.1371/journal.pone.0157478
PMCID: PMC4900521

Genes

GSTP1

Provenance

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