Article
Association between NR1I2 polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity in an Eastern Chinese Han population: A case-control study.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Sept 2020
Yang Miaomiao, Pan Hongqiu, Chen Hongbo, Liu Wenpei, Lu Lihuan, He Xiaomin, Yi Honggang, Tang Shaowen
Abstract excerpt
OBJECTIVE: Anti-tuberculosis drug-induced hepatotoxicity (ATDH) is a serious adverse drug reaction, and its pathogenic mechanism is still largely unknown. Pregnane X receptor (PXR, encoded by the NR1I2 gene) is a ligand-dependent transcription factor, and rifampicin is a human PXR-specific activator. Rifampicin and isoniazid co-therapy targets porphyrin biosynthesis via PXR and results in hepatic protoporphyrin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.