A validation study of the UGT1A4 rs2011404 variant and the risk of anti-tuberculosis drug-induced hepatotoxicity in an Eastern Chinese Han population.

doi:10.1111/jcpt.13452

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Article

A validation study of the UGT1A4 rs2011404 variant and the risk of anti-tuberculosis drug-induced hepatotoxicity in an Eastern Chinese Han population.

Journal of clinical pharmacy and therapeutics - 1 Oct 2021

Zhu Jia, Liu Wenpei, Zhang Meiling, Lu Lihuan, Pan Hongqiu, He Xiaomin, Wang Nannan, Yang Miaomiao, Yi Honggang, Tang Shaowen

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Anti-tuberculosis (anti-TB) drug-induced hepatotoxicity (ATDH) is a serious adverse drug reaction. A recent study found that the rs2011404 variant of uridine 5'-diphospho-glucuronosyl-transferase 1A4 (UGT1A4) is a marker of susceptibility to ATDH. The present study aimed to validate this relationship in an Eastern Chinese Han anti-TB treatment population. METHODS: A 1:4 matched...

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PMID: 34046917
DOI: 10.1111/jcpt.13452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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