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Article

Gender-Dimorphic Impact of PXR Genotype and Haplotype on Hepatotoxicity During Antituberculosis Treatment.

Medicine - 1 Jun 2015

Wang Jann Yuan, Tsai Ching Hui, Lee Yungling Leo, Lee Li Na, Hsu Chia Lin, Chang Hsiu Ching, Chen Jong Ming, Hsu Cheng An, Yu Chong Jen, Yang Pan Chyr

Abstract excerpt

Women have a higher risk of drug-induced hepatotoxicity during antituberculosis treatment (HATT) than men. We hypothesized that single nucleotide polymorphism (SNP) genotype and derived haplotype of pregnane X receptor (PXR) gene, which could regulate the expression of phase I enzyme cytochrome P450 (CYP) 3A4, had a sex-specific influence on the risk of HATT. Six SNPs of the PXR gene were sequenced. Genotypes and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26091473
DOI: 10.1097/MD.0000000000000982
PMCID: PMC4616541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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