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Article

Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis.

Nucleic acids research - 16 Dec 2021

Carroll Brittany L, Zahn Karl E, Hanley John P, Wallace Susan S, Dragon Julie A, Doublié Sylvie

Abstract excerpt

Base excision repair (BER) is the main pathway protecting cells from the continuous damage to DNA inflicted by reactive oxygen species. BER is initiated by DNA glycosylases, each of which repairs a particular class of base damage. NTHL1, a bifunctional DNA glycosylase, possesses both glycolytic and β-lytic activities with a preference for oxidized pyrimidine substrates. Defects in human NTHL1 drive a class of...

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Identifiers

PMID: 34871433
DOI: 10.1093/nar/gkab1162
PMCID: PMC8682792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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