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Article

NTHL1 in genomic integrity, aging and cancer.

DNA repair - 1 Sept 2020

Das Lipsa, Quintana Victoria G, Sweasy Joann B

Abstract excerpt

Efficient DNA repair is essential to maintain genomic integrity. An average of 30,000 base lesions per cell are removed daily by the DNA glycosylases of the base excision repair machinery. With the advent of whole genome sequencing, many germline mutations in these DNA glycosylases have been identified and associated with various diseases, including cancer. In this graphical review, we discuss the function of the...

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Identifiers

PMID: 33087284
DOI: 10.1016/j.dnarep.2020.102920
PMCID: PMC7748067

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