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Article

Probing the activity of NTHL1 orthologs by targeting conserved amino acid residues.

DNA repair - 1 May 2017

Robey-Bond Susan M, Benson Meredith A, Barrantes-Reynolds Ramiro, Bond Jeffrey P, Wallace Susan S

Abstract excerpt

The base excision repair DNA glycosylases, EcoNth and hNTHL1, are homologous, with reported overlapping yet different substrate specificities. The catalytic amino acid residues are known and are identical between the two enzymes although the exact structures of the substrate binding pockets remain to be determined. We sought to explore the sequence basis of substrate differences using a phylogeny-based design of...

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Identifiers

PMID: 28292631
DOI: 10.1016/j.dnarep.2017.02.014
PMCID: PMC5421317

Genes

NTHL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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