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Article

Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine.

Free radical biology & medicine - 1 Jun 2017

Banda Douglas M, Nuñez Nicole N, Burnside Michael A, Bradshaw Katie M, David Sheila S

Abstract excerpt

Reactive oxygen and nitrogen species (RONS) may infringe on the passing of pristine genetic information by inducing DNA inter- and intra-strand crosslinks, protein-DNA crosslinks, and chemical alterations to the sugar or base moieties of DNA. 8-Oxo-7,8-dihydroguanine (8-oxoG) is one of the most prevalent DNA lesions formed by RONS and is repaired through the base excision repair (BER) pathway involving the DNA...

Topics

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Adenomatous Polyposis Coli
Catalysis
Colorectal Neoplasms
DNA Glycosylases
DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reactive Oxygen Species

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Identifiers

PMID: 28087410
DOI: 10.1016/j.freeradbiomed.2017.01.008
PMCID: PMC5457711

Genes

MUTYH
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Related research

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Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine.PMID 28087410Read ↗

The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.Semantic proximity Read ↗

MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNASemantic proximity Read ↗

Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer.Semantic proximity Read ↗

Structural Connectivity Between the Zinc Linchpin Motif, the [4Fe-4S] cluster, and the active site orchestrates DNA repair in MUTYHSemantic proximity Read ↗

Role of MUTYH in human cancer.Semantic proximity Read ↗

MUTYH cancer-associated variants within the interdomain connector differentially impact glycosylase activity and cellular DNA repairSemantic proximity Read ↗

MUTYH Cancer-Associated Variants Within the Interdomain Connector Differentially Impact Glycosylase Activity and Cellular DNA Repair.Semantic proximity Read ↗

[GO System, a DNA Repair Pathway to Cope with Oxidative Damage].Semantic proximity Read ↗

Saturation mapping of <i>MUTYH</i> variant effects using DNA repair reportersSemantic proximity Read ↗

Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair.Semantic proximity Read ↗

Oxidative stress accelerates intestinal tumorigenesis by enhancing 8-oxoguanine-mediated mutagenesis in MUTYH-deficient mice.Semantic proximity Read ↗

[Inherited mutations of MUTYH and colorectal cancer].Semantic proximity Read ↗

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