Article
Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer.
Nucleic acids research - 18 May 2018
Limpose Kristin L, Trego Kelly S, Li Zhentian, Leung Sara W, Sarker Altaf H, Shah Jason A, Ramalingam Suresh S, Werner Erica M, Dynan William S, Cooper Priscilla K, Corbett Anita H, Doetsch Paul W
Abstract excerpt
Base excision repair (BER), which is initiated by DNA N-glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. The NTHL1 glycosylase, which excises DNA base damage caused by reactive oxygen species, is thought to be a tumor suppressor. However, in addition to NTHL1 loss-of-function mutations, our analysis of cancer genomic datasets reveals that NTHL1 frequently undergoes...
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