Article

Unique structural features of mammalian NEIL2 DNA glycosylase prime its activity for diverse DNA substrates and environments

2020-02-28

Abstract excerpt

<h4>SUMMARY</h4> Oxidative damage on DNA arising from both endogenous and exogenous sources can result in base modifications that promote errors in replication as well as generate sites of base loss (abasic sites) that present unique challenges to maintaining genomic integrity. These lesions are excised by DNA glycosylases in the first step of the base excision repair pathway. Here we present the first crystal st...

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Literature Corpus work: a44c03cb-b47e-5474-8c15-4c79eb669c04
DOI: 10.1101/2020.02.28.970129

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