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Methylation quantitative locus rs3758653 in the DRD4 gene is associated with duration from first heroin exposure to addiction.

Brain research - 15 Jan 2022

Zhang Rui, Dang Wei, Zhang Jianbo, He Ruifeng, Li Guibin, Zhang Luying, Wang Zhikang, Zong Hua, Liu Ning, Jia Wei

Abstract excerpt

Opioid addiction is a chronic brain disease with a high heritability. However, the genetic underpinnings remain uncertain. DNA methylation is involved in the adaptive changes in neuroplasticity after prolonged drug use. The dopamine receptor D4 (DRD4) has an essential role in the reward processes associated with addictive drugs. To further elucidate the potential role and mechanism of the DRD4 gene variants in...

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Identifiers

PMID: 34864042
DOI: 10.1016/j.brainres.2021.147746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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