Article
Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese.
Omics : a journal of integrative biology - 1 Jul 2017
Gao Xuan, Wang Youxin, Lang Minglin, Yuan Li, Reece Albert Stuart, Wang Wei
Abstract excerpt
Heroin and drug dependence are major contributors to global health burden worldwide, but their underlying mechanisms remain elusive and may vary from population to population. Reward- and memory-related candidate genes dopamine D2 receptor (DRD2) and brain-derived neurotrophic factor (BDNF), as well as the opioid receptor genes (OPRM1, OPRD1, and OPRK1), have been implicated in drug dependence, but relatively...
Topics
- Alleles
- Brain-Derived Neurotrophic Factor
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide