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Article

Opioid Exposure is Associated with Aberrant DNA Methylation of OPRM1 Promoter Region in a Chinese Han Population.

Biochemical genetics - 1 Oct 2018

Xu Jiawei, Wang Teng, Su Zhiyang, Zhou Xinyao, Xiang Yuqian, He Lin, Li Candong, Yang Zhaoyang, Zhao Xinzhi

Abstract excerpt

The μ-opioid receptor (OPRM1) plays an important role in opiate addiction. The OPRM1 gene promoter showed hypermethylation in lymphocytes of opiate addicts as well as opioid medications users, while the methylation status displayed ethnic diversity. The purpose of the study was to investigate the methylation pattern of OPRM1 promoter in the Han Chinese population. We analyzed 22 CpG sites located in OPRM1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29564682
DOI: 10.1007/s10528-018-9852-y

Genes

OPRM1

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