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Article

Methylation quantitative trait locus rs5326 is associated with susceptibility and effective dosage of methadone maintenance treatment for heroin use disorder.

Psychopharmacology - 1 Dec 2021

Zhang Jianbo, Fan Yajuan, Zhou Jinting, Ma Tengfei, Gao Keqiang, Xu Min, Xiao Yifan, Zhu Yongsheng

Abstract excerpt

RATIONALE: Opioid use disorder is a complicated brain disease with high heritability. The underlying mechanisms of the genetic underpinnings in the susceptibility and treatment response of opioid use disorder remain elusive. OBJECTIVES: To reveal the potential associations of genotypes and gene methylations of dopaminergic system genes, as well as roles of them in opioid use disorder. In the present study, we...

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Share to DNA Methylation
Share to Dopamine Plasma Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heroin Dependence

Share to Methadone

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 34476566
DOI: 10.1007/s00213-021-05968-8

Genes

DRD1
DRD2
COMT
SLC6A3
TH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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