Article
Methylation and expression quantitative trait loci rs1799971 in the OPRM1 gene and rs4654327 in the OPRD1 gene are associated with opioid use disorder.
Neuroscience letters - 25 Sept 2023
Yu Jiao, Zhang Yudan, Xun Yufeng, Tang Hua, Fu Xiaoyu, Zhang Rui, Zhu Feng, Zhang Jianbo
Abstract excerpt
Opioid use disorder (OUD) is a chronic and relapsing brain disease that results in significant mortality worldwide. Genetic factors are estimated to contribute to 40%-60% of the liability, with polymorphisms of opioid receptor genes implicated in this disorder. However, the mechanisms underlying these associations are not yet fully understood. In the present study, we first examined the methylation levels in the...
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