Article
Functional Gly297Ser Variant of the Physiological Dysglycemic Peptide Pancreastatin Is a Novel Risk Factor for Cardiometabolic Disorders.
Diabetes - 1 Mar 2022
Allu Prasanna K R, Kiranmayi Malapaka, Mukherjee Sromona D, Chirasani Venkat R, Garg Richa, Vishnuprabu Durairajpandian, Ravi Sudesh, Subramanian Lakshmi, Sahu Bhavani S, Iyer Dhanya R, Maghajothi Sakthisree, Sharma Saurabh, Ravi Marimuthu S, Khullar Madhu, Munirajan Arasambattu K, Gayen Jiaur R, Senapati Sanjib, Mullasari Ajit S, Mohan Viswanathan, Radha Venkatesan, Naga Prasad Sathyamangala V, Mahapatra Nitish R
Abstract excerpt
Pancreastatin (PST), a chromogranin A-derived potent physiological dysglycemic peptide, regulates glucose/insulin homeostasis. We have identified a nonsynonymous functional PST variant (p.Gly297Ser; rs9658664) that occurs in a large section of human populations. Association analysis of this single nucleotide polymorphism with cardiovascular/metabolic disease states in Indian populations (n = 4,300 subjects)...
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