Article
Pancreastatin: multiple actions on human intermediary metabolism in vivo, variation in disease, and naturally occurring functional genetic polymorphism.
The Journal of clinical endocrinology and metabolism - 1 Sept 2005
O'Connor Daniel T, Cadman Peter E, Smiley Clayton, Salem Rany M, Rao Fangwen, Smith Joshua, Funk Stephen D, Mahata Sushil K, Mahata Manjula, Wen Gen, Taupenot Laurent, Gonzalez-Yanes Carmen, Harper Kimberly L, Henry Robert R, Sanchez-Margalet Victor
Abstract excerpt
RATIONALE: The chromogranin A (CHGA) fragment pancreastatin (human CHGA250-301) impairs glucose metabolism, but the role of human pancreastatin in vivo remains unexplored. METHODS: We studied brachial arterial infusion of pancreastatin (CHGA273-301-amide at approximately 200 nm) on forearm metabolism of glucose, free fatty acids, and amino acids. Plasma pancreastatin was measured in obesity or type 2 diabetes....
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