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Article

Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease.

Diabetes - 1 Aug 2017

Emdin Connor A, Klarin Derek, Natarajan Pradeep, Florez Jose C, Kathiresan Sekar, Khera Amit V

Abstract excerpt

Despite widespread clinical use in the treatment of type 2 diabetes, the impact of sulfonylurea therapy on cardiovascular outcomes remains uncertain. Studies of naturally occurring genetic variation can be used to anticipate the expected clinical consequences of a pharmacological therapy. A common missense variant in the gene encoding a component of the sulfonylurea receptor (ABCC8 p.A1369S) promotes closure of...

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Source

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Identifiers

PMID: 28411266
DOI: 10.2337/db17-0149
PMCID: PMC5521864

Genes

ABCC8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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