Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biological and biochemical functions of RNA in the tetrahymena telomerase holoenzyme.

Molecular and cellular biology - 1 Jun 2005

Cunningham Doreen D, Collins Kathleen

Abstract excerpt

Telomerase extends chromosome ends by the synthesis of tandem simple-sequence repeats. Studies of minimal recombinant telomerase ribonucleoprotein (RNP) reconstituted in vitro have revealed sequences within the telomerase RNA subunit (TER) that are required to establish its internal template and other unique features of enzyme activity. Here we test the significance of these motifs following TER assembly into...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Holoenzymes
Share to Phosphoproteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protozoan Proteins

Share to Ribonucleoproteins

Share to Telomerase

Share to Templates, Genetic

Share to Tetrahymena thermophila

Source

Open in PubMed Open full text

Identifiers

PMID: 15899850
DOI: 10.1128/MCB.25.11.4442-4454.2005
PMCID: PMC1140614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biological and biochemical functions of RNA in the tetrahymena telomerase holoenzyme.PMID 15899850Read ↗

RNA Binding Domain of Telomerase Reverse TranscriptaseSemantic proximity Read ↗

A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.Semantic proximity Read ↗

Positive and negative regulation of Tetrahymena telomerase holoenzyme.Semantic proximity Read ↗

Structure and function of telomerase RNA.Semantic proximity Read ↗

In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei.Semantic proximity Read ↗

Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase.Semantic proximity Read ↗

Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate.Semantic proximity Read ↗

Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme.Semantic proximity Read ↗

Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants.Semantic proximity Read ↗

Telomerase as a DNA-dependent DNA polymerase.Semantic proximity Read ↗

Engineering cis-telomerase RNAs that add telomeric repeats to themselves.Semantic proximity Read ↗

Disease-associated human telomerase RNA variants show loss of function for telomere synthesis without dominant-negative interference.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.