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Article

Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi‡.

Nucleic acids research - 7 May 2021

Zhai Liu-Tao, Rety Stephane, Chen Wei-Fei, Song Ze-Yu, Auguin Daniel, Sun Bo, Dou Shuo-Xing, Xi Xu-Guang

Abstract excerpt

Telomerase plays critical roles in cellular aging, in the emergence and/or development of cancer, and in the capacity for stem-cell renewal, consists of a catalytic telomerase reverse transcriptase (TERT) and a template-encoding RNA (TER). TERs from diverse organisms contain two conserved structural elements: the template-pseudoknot (T-PK) and a helical three-way junction (TWJ). Species-specific features of the...

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PMID: 33856462
DOI: 10.1093/nar/gkab261
PMCID: PMC8096264

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