Dynamic RNA holo‐editosomes with subcomplex variants: Insights into the control of trypanosome editing

Abstract excerpt

RNA editing causes massive remodeling of the mitochondrial mRNA transcriptome in trypanosomes and related kinetoplastid protozoa. This type of editing involves the specific insertion or deletion of uridylates (U) directed by small noncoding guide RNAs (gRNAs). Because U-insertion exceeds U-deletion by a factor of 10, editing increases the nascent mRNA size by up to 55%. In Trypanosoma brucei, the editing...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to RNA regulation and disease
• Share to Trypanosoma species research and implications
• Share to Viral Infections and Immunology Research