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Article

Cryo-EM structure of substrate-bound human telomerase holoenzyme.

Nature - 1 May 2018

Nguyen Thi Hoang Duong, Tam Jane, Wu Robert A, Greber Basil J, Toso Daniel, Nogales Eva, Collins Kathleen

Abstract excerpt

The enzyme telomerase adds telomeric repeats to chromosome ends to balance the loss of telomeres during genome replication. Telomerase regulation has been implicated in cancer, other human diseases, and ageing, but progress towards clinical manipulation of telomerase has been hampered by the lack of structural data. Here we present the cryo-electron microscopy structure of the substrate-bound human telomerase...

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Identifiers

PMID: 29695869
DOI: 10.1038/s41586-018-0062-x
PMCID: PMC6223129

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TERT

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