Article
Polygenic Risk Score Contribution to Psychosis Prediction in a Target Population of Persons at Clinical High Risk.
The American journal of psychiatry - 1 Feb 2020
Perkins Diana O, Olde Loohuis Loes, Barbee Jenna, Ford John, Jeffries Clark D, Addington Jean, Bearden Carrie E, Cadenhead Kristin S, Cannon Tyrone D, Cornblatt Barbara A, Mathalon Daniel H, McGlashan Thomas H, Seidman Larry J, Tsuang Ming, Walker Elaine F, Woods Scott W
Abstract excerpt
OBJECTIVE: The 2-year risk of psychosis in persons who meet research criteria for a high-risk syndrome is about 15%-25%; improvements in risk prediction accuracy would benefit the development and implementation of preventive interventions. The authors sought to assess polygenic risk score (PRS) prediction of subsequent psychosis in persons at high risk and to determine the impact of adding the PRS to a previously...
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