Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Insertion in the Hepatitis B Virus Surface Protein Leading to Hyperglycosylation Causes Diagnostic and Immune Escape.

Viruses - 25 Mar 2023

Lehmann Felix, Slanina Heiko, Roderfeld Martin, Roeb Elke, Trebicka Jonel, Ziebuhr John, Gerlich Wolfram H, Schüttler Christian G, Schlevogt Bernhard, Glebe Dieter

Abstract excerpt

Chronic hepatitis B virus (HBV) infection is a global health threat. Mutations in the surface antigen of HBV (HBsAg) may alter its antigenicity, infectivity, and transmissibility. A patient positive for HBV DNA and detectable but low-level HBsAg in parallel with anti-HBs suggested the presence of immune and/or diagnostic escape variants. To support this hypothesis, serum-derived HBs gene sequences were amplified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B
Share to Hepatitis B Antibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B Surface Antigens

Share to Hepatitis B Vaccines

Share to Hepatitis B virus

Share to Immunologic Factors

Share to Nucleotides

Source

Open in PubMed Open full text

Identifiers

PMID: 37112819
DOI: 10.3390/v15040838
PMCID: PMC10144012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Insertion in the Hepatitis B Virus Surface Protein Leading to Hyperglycosylation Causes Diagnostic and Immune Escape.PMID 37112819Read ↗

N-glycosylation mutations within hepatitis B virus surface major hydrophilic region contribute mostly to immune escape.Semantic proximity Read ↗

Analysis of the Physicochemical Properties, Replication and Pathophysiology of a Massively Glycosylated Hepatitis B Virus HBsAg Escape Mutant.Semantic proximity Read ↗

In vitro and in silico analyses of amino acid substitution effects at the conserved N-linked glycosylation site in hepatitis B virus surface protein on antigenicity, immunogenicity, HBV replication and secretion.Semantic proximity Read ↗

N-Glycosylation and N-Glycan Processing in HBV Biology and PathogenesisSemantic proximity Read ↗

Comprehensive analysis of the prevalence of hepatitis B virus escape mutations in the major hydrophilic region of surface antigen.Semantic proximity Read ↗

N-Linked Glycosylation at an Appropriate Position in the Pre-S2 Domain Is Critical for Cellular and Humoral Immunity against Middle HBV Surface Antigen.Semantic proximity Read ↗

Characterization of a novel hepatitis B virus mutant: demonstration of mutation-induced hepatitis B virus surface antigen group specific "a" determinant conformation change and its application in diagnostic assays.Semantic proximity Read ↗

A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition in Vitro.Semantic proximity Read ↗

The Impact of HBV Quasispecies Features on Immune Status in HBsAg+/HBsAb+ Patients With HBV Genotype C Using Next-Generation Sequencing.Semantic proximity Read ↗

Genetic variation of hepatitis B surface antigen among acute and chronic hepatitis B virus infections in The Netherlands.Semantic proximity Read ↗

Unique surface gene variants of hepatitis B virus isolated from patients in the Philippines.Semantic proximity Read ↗

Exchanges in the 'a' determinant of the hepatitis B virus surface antigen revisited.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.