Article

Loss of Tau Expression Attenuates Neurodegeneration Associated With α-Synucleinopathy

2022-01-19

Abstract excerpt

<h4>Background: </h4> Neuronal dysfunction and degeneration linked to α-synuclein (αS) pathology is thought to be responsible for the progressive nature of Parkinson’s Disease and related Dementia with Lewy Bodies. Studies indicate to bidirectional pathological relationships between αS pathology and tau abnormalities. We recently showed that A53T mutant human αS (HuαS) can cause post-synaptic and cognitive deficit...

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Literature Corpus work: cc8110b5-ca18-5967-8775-61a8ed832289
DOI: 10.21203/rs.3.rs-1150251/v2

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