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Article

α-Synuclein Oligomers Induce a Unique Toxic Tau Strain

16 Jan 2018

Abstract excerpt

BACKGROUND: The coexistence of α-synuclein and tau aggregates in several neurodegenerative disorders, including Parkinson's disease and Alzheimer's disease, raises the possibility that a seeding mechanism is involved in disease progression. METHODS: To further investigate the role of α-synuclein in the tau aggregation pathway, we performed a set of experiments using both recombinant and brain-derived tau and...

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PMID: 29478699
DOI: 10.1016/j.biopsych.2017.12.018

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