Article
Dissecting the function and interactome of PLEKHS1 in prostate tumorigenesis
2021-01-01
Abstract excerpt
Phosphatidylinositol(3,4,5)trisphosphate (PI(3,4,5)P3 or PIP3) is the lipid product and key signalling output of Class I phosphoinositide 3-kinases (PI3Ks) and acts as a coordinator of a huge network that controls cellular processes such as metabolism, cell growth and movement. Mutations that augment the activity of this network are amongst the most common drivers of tumour progression. Upon binding of many ligand...
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Identifiers and source
- Literature Corpus work
- ee5143d5-04b6-5de4-8b21-df3abe3da957
- DOI
- 10.17863/cam.63289