Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes.

The Journal of cell biology - 23 Mar 2009

Lu Albert, Tebar Francesc, Alvarez-Moya Blanca, López-Alcalá Cristina, Calvo Maria, Enrich Carlos, Agell Neus, Nakamura Takeshi, Matsuda Michiyuki, Bachs Oriol

Abstract excerpt

Ras proteins are small guanosine triphosphatases involved in the regulation of important cellular functions such as proliferation, differentiation, and apoptosis. Understanding the intracellular trafficking of Ras proteins is crucial to identify novel Ras signaling platforms. In this study, we report that epidermal growth factor triggers Kirsten Ras (KRas) translocation onto endosomal membranes (independently of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androstenes
Share to Calmodulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clathrin

Share to GRB2 Adaptor Protein

Share to Macrolides

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Proto-Oncogene Proteins c-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 19289794
DOI: 10.1083/jcb.200807186
PMCID: PMC2699148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes.PMID 19289794Read ↗

Dynamics of KRas on endosomes: involvement of acidic phospholipids in its association.Semantic proximity Read ↗

An Emerging Role of KRAS in Biogenesis, Cargo Sorting and Uptake of Cancer-Derived Extracellular VesiclesSemantic proximity Read ↗

Oncogenic RAS induces a distinctive form of non-canonical autophagy mediated by the P38-ULK1-PI4KB axisSemantic proximity Read ↗

The G protein-coupled receptor GPR31 promotes membrane association of KRAS.Semantic proximity Read ↗

Rasosomes originate from the Golgi to dispense Ras signals.Semantic proximity Read ↗

Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.Semantic proximity Read ↗

DHHC7 palmitoylates KRAS4A and promotes mutant KRAS-driven pancreatic cancersSemantic proximity Read ↗

Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistanceSemantic proximity Read ↗

Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS MutationsSemantic proximity Read ↗

Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras.Semantic proximity Read ↗

KRAS G12C and KRAS G12D respond to lipid metabolism in an allele-specific manner.Semantic proximity Read ↗

PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.